BDBM50258312 CHEMBL4095528

SMILES NC(=O)C(=O)C(Cc1ccccc1)NC(=O)c1cccnc1-n1ccc(n1)-c1ccccc1

InChI Key InChIKey=YAJUREDVHDQEOI-UHFFFAOYSA-N

Data  3 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50258312   

TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Abbvie Deutschland

Curated by ChEMBL
LigandPNGBDBM50258312(CHEMBL4095528)
Affinity DataKi:  18nMAssay Description:Inhibition of human erythrocytes calpain-1 using Suc-Leu-Tyr-AMC as substrate by kinetic fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Abbvie Deutschland

Curated by ChEMBL
LigandPNGBDBM50258312(CHEMBL4095528)
Affinity DataKi:  18nMAssay Description:Inhibition of Calpain I (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Abbvie Deutschland

Curated by ChEMBL
LigandPNGBDBM50258312(CHEMBL4095528)
Affinity DataKi:  18nMAssay Description:Inhibition of human erythrocyte calpain 1 using Suc-Leu-Tyr-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Rattus norvegicus)
Abbvie Deutschland

Curated by ChEMBL
LigandPNGBDBM50258312(CHEMBL4095528)
Affinity DataIC50:  971nMAssay Description:Inhibition of calpain-1 in rat hippocampal slices assessed as prevention of NMDA-induced spectrin cleavage preincubated for 30 mins followed by NMDA ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed