BDBM50258510 8-(4-tert-butylbenzoyl)-3-(2-oxo-2-(piperidin-1-yl)ethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one::CHEMBL468523

SMILES CC(C)(C)c1ccc(cc1)C(=O)N1CCC2(CC1)N(CN(CC(=O)N1CCCCC1)C2=O)c1ccccc1

InChI Key InChIKey=BNIJUNMGPGDSQV-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50258510   

TargetNPC1-like intracellular cholesterol transporter 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50258510(8-(4-tert-butylbenzoyl)-3-(2-oxo-2-(piperidin-1-yl...)
Affinity DataIC50:  2.50E+3nMAssay Description:Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-(4-(3-(methylsulfonamido)prop-1-ynyl)phenyl)-4-oxoaz...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNPC1-like intracellular cholesterol transporter 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50258510(8-(4-tert-butylbenzoyl)-3-(2-oxo-2-(piperidin-1-yl...)
Affinity DataIC50:  1.00E+4nMAssay Description:Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-(4-(3-(methylsulfonamido)prop-1-ynyl)phenyl)-4-oxoaz...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNiemann-Pick C1-like 1 protein(Macaca mulatta)
Merck

Curated by ChEMBL
LigandPNGBDBM50258510(8-(4-tert-butylbenzoyl)-3-(2-oxo-2-(piperidin-1-yl...)
Affinity DataIC50:  7.70E+4nMAssay Description:Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-(4-(3-(methylsulfonamido)prop-1-ynyl)phenyl)-4-oxoaz...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNPC1-like intracellular cholesterol transporter 1(Rattus norvegicus)
Merck

Curated by ChEMBL
LigandPNGBDBM50258510(8-(4-tert-butylbenzoyl)-3-(2-oxo-2-(piperidin-1-yl...)
Affinity DataIC50:  1.10E+5nMAssay Description:Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-(4-(3-(methylsulfonamido)prop-1-ynyl)phenyl)-4-oxoaz...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNiemann-Pick C1-like 1 protein(Canis familiaris)
Merck

Curated by ChEMBL
LigandPNGBDBM50258510(8-(4-tert-butylbenzoyl)-3-(2-oxo-2-(piperidin-1-yl...)
Affinity DataIC50:  1.70E+5nMAssay Description:Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-(4-(3-(methylsulfonamido)prop-1-ynyl)phenyl)-4-oxoaz...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNPC1-like intracellular cholesterol transporter 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50258510(8-(4-tert-butylbenzoyl)-3-(2-oxo-2-(piperidin-1-yl...)
Affinity DataIC50:  2.50E+3nMAssay Description:Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-(4-(3-(methylsulfonamido)prop-1-ynyl)phenyl)-4-oxoaz...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed