BDBM50261195 1-{2-[(1S)-(3-Dimethylaminopropionamino)-2-methylpropyl]-6-fluorophenyl}-4-[(2R)-methyl-3-(4-chlorophenyl)propionyl]piperazine::CHEMBL497746

SMILES CC(C)[C@H](NC(=O)CCN(C)C)c1cccc(F)c1N1CCN(CC1)C(=O)[C@H](C)Cc1ccc(Cl)cc1

InChI Key InChIKey=ROSDSGGMKIYLIM-ZBLYBZFDSA-N

Data  8 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50261195   

TargetMelanocortin receptor 4(Mus musculus)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50261195(1-{2-[(1S)-(3-Dimethylaminopropionamino)-2-methylp...)
Affinity DataKi:  3.5nMAssay Description:Binding affinity at mouse MC4RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Rattus norvegicus)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50261195(1-{2-[(1S)-(3-Dimethylaminopropionamino)-2-methylp...)
Affinity DataKi:  5.5nMAssay Description:Binding affinity at rat MC4RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50261195(1-{2-[(1S)-(3-Dimethylaminopropionamino)-2-methylp...)
Affinity DataKi:  7.5nMAssay Description:Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 3(Mus musculus)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50261195(1-{2-[(1S)-(3-Dimethylaminopropionamino)-2-methylp...)
Affinity DataKi:  190nMAssay Description:Binding affinity at mouse MC3RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50261195(1-{2-[(1S)-(3-Dimethylaminopropionamino)-2-methylp...)
Affinity DataKi:  240nMAssay Description:Inhibition of ghrelin receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 3(Rattus norvegicus)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50261195(1-{2-[(1S)-(3-Dimethylaminopropionamino)-2-methylp...)
Affinity DataKi:  340nMAssay Description:Binding affinity at rat MC3RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 3(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50261195(1-{2-[(1S)-(3-Dimethylaminopropionamino)-2-methylp...)
Affinity DataKi:  490nMAssay Description:Displacement of [125I]NDP-MSH from human MC3R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50261195(1-{2-[(1S)-(3-Dimethylaminopropionamino)-2-methylp...)
Affinity DataKi:  1.10E+3nMAssay Description:Displacement of [125I]NDP-MSH from human MC5R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50261195(1-{2-[(1S)-(3-Dimethylaminopropionamino)-2-methylp...)
Affinity DataIC50:  270nMAssay Description:Antagonist activity at human MC4R expressed in CHO cells assessed as inhibition of alpha-MSH-induced cAMP production by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed