BDBM50261215 CHEMBL2387223

SMILES F[C@@H]1C[C@@H]1C(=O)Nc1cc(NC(=O)c2c(F)cc(cc2Cl)C#N)ccn1

InChI Key InChIKey=NKALKXMQBFLGQI-CMPLNLGQSA-N

Data  2 KI  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50261215   

TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50261215(CHEMBL2387223)
Affinity DataKi:  1.60nMAssay Description:Inhibition of TYK2 (unknown origin) assessed as reduction in IL-23 induced STAT3 phosphorylation by cell based ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50261215(CHEMBL2387223)
Affinity DataKi:  62nMAssay Description:Inhibition of JAK2 (unknown origin) by biochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50261215(CHEMBL2387223)
Affinity DataEC50:  1.20E+3nMAssay Description:Inhibition of JAK2 (unknown origin) assessed as reduction in EPO-mediated STAT5 phosphorylation by cell based readout assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50261215(CHEMBL2387223)
Affinity DataEC50:  2.25E+3nMAssay Description:Inhibition of JAK2 (unknown origin) by biochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50261215(CHEMBL2387223)
Affinity DataEC50:  224nMAssay Description:Inhibition of TYK2 (unknown origin) assessed as reduction in IL-12 induced STAT4 phosphorylation by cell based ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed