BDBM50262048 CHEMBL3134377
SMILES Cc1ccc(cc1)-c1ncc(OC[C@@H]2CCNC2)cc1-c1ccc(cc1)C#N
InChI Key InChIKey=IQVDLEXWAPYWDT-LJQANCHMSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 7 hits for monomerid = 50262048
Affinity DataKi: 35nMAssay Description:Inhibition of human LSD1/CoREST using histone H3 peptide as substrate by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University of Manchester
Curated by ChEMBL
University of Manchester
Curated by ChEMBL
Affinity DataIC50: 3.20E+3nMAssay Description:Displacement of [125I]-L-691831 from human FLAP expressed in Sf9 cell membranes after 2 hrs by Topcount methodMore data for this Ligand-Target Pair
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University of Manchester
Curated by ChEMBL
University of Manchester
Curated by ChEMBL
Affinity DataKd: 8nMAssay Description:Inhibition of recombinant human N-terminal truncated LSD1 (151 to 852 residues) expressed in Escherichia coli using histone H3(1-21)K4(Me1) biotin pe...More data for this Ligand-Target Pair
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University of Manchester
Curated by ChEMBL
University of Manchester
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of LSD1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKd: 14nMAssay Description:Binding affinity to human LSD1/CoREST assessed as dissociation constant by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University of Manchester
Curated by ChEMBL
University of Manchester
Curated by ChEMBL
Affinity DataIC50: 41nMAssay Description:Inhibition of recombinant human N-terminal truncated LSD1 (151 to 852 residues) expressed in Escherichia coli using histone H3(1-21)K4(Me1) biotin pe...More data for this Ligand-Target Pair
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University of Manchester
Curated by ChEMBL
University of Manchester
Curated by ChEMBL
Affinity DataEC50: 62nMAssay Description:Inhibition of LSD1 in human THP1 cells assessed as induction of CD11b expression after 4 days by LIVE/DEAD violet staining based FACS analysisMore data for this Ligand-Target Pair