BDBM50262079 4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline::4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline::CHEMBL513147::LDN-193189

SMILES C1CN(CCN1)c1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12

InChI Key InChIKey=CDOVNWNANFFLFJ-UHFFFAOYSA-N

Data  38 IC50  4 EC50

PDB links: 4 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50262079   

TargetReceptor protein serine/threonine kinase(Danio rerio (Zebrafish))
Vanderbilt University

LigandPNGBDBM50262079(4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...)
Affinity DataEC50:  3.00E+3nMAssay Description:The effects on zebrafish embryos with respect to the dorsoventral (DV) axis. For dorsalization, the EC100 (effective concentration 100%) represents t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor protein serine/threonine kinase(Danio rerio (Zebrafish))
Vanderbilt University

LigandPNGBDBM50262079(4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...)
Affinity DataEC50:  2.00E+4nMAssay Description:For nonspecific toxicity, the EC100 represents the concentration when 100% of the treated embryos exhibit either early lethality within hours of comp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetActivin receptor type-1(Mus musculus)
Massachusetts Institute of Technology

LigandPNGBDBM50262079(4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...)
Affinity DataEC50:  14nMAssay Description:Inhibition of BMP6-induced ALK2 transcriptional activity in mouse C2C12 cells expressing BRE-Luc after 30 mins by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetReceptor protein serine/threonine kinase(Danio rerio (Zebrafish))
Vanderbilt University

LigandPNGBDBM50262079(4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...)
Affinity DataEC50:  2.00E+4nMAssay Description:For ISV disruption, the EC50 represents the concentration when the formation of about 50% of the ISVs is inhibited.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed