BDBM50263004 CHEMBL4069936
SMILES Cc1ncc(F)cc1NC(=O)C[C@@H](C1CC1)C(=O)N[C@H]1c2ccccc2C(=O)N2CC3(CC3)CN2C1=O
InChI Key InChIKey=WLQXBRYTQYYCMW-REWPJTCUSA-N
Data 6 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 50263004
TargetSignal peptide peptidase-like 2A(Homo sapiens)
The Genomics Institute of The Novartis Research Foundation
Curated by ChEMBL
The Genomics Institute of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 77nMAssay Description:Inhibition of human SPPL2a expressed in HEK293 cells using GAL4-VP16 fusedTNFalpha (1 to 76)-NTF as substrate after 24 hrs by Bright-Glo luciferase r...More data for this Ligand-Target Pair
TargetSimilar to RIKEN cDNA 2010106G01 (Predicted)(Rattus norvegicus)
The Genomics Institute of The Novartis Research Foundation
Curated by ChEMBL
The Genomics Institute of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 56nMAssay Description:Inhibition of rat SPPL2a expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 77 residues) NLS as substrate after 24 hrs by Hoechst staini...More data for this Ligand-Target Pair
TargetSignal peptide peptidase-like 2A(Homo sapiens)
The Genomics Institute of The Novartis Research Foundation
Curated by ChEMBL
The Genomics Institute of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 77nMAssay Description:Inhibition of human ERG expressed in HEK293 cells assessed as decrease in peak tail current amplitude by path clamp methodMore data for this Ligand-Target Pair
TargetSignal peptide peptidase-like 2B(Homo sapiens)
The Genomics Institute of The Novartis Research Foundation
Curated by ChEMBL
The Genomics Institute of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 430nMAssay Description:Inhibition of human SPPL2b expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 76 residues) NTF as substrate after 24 hrs by Hoechst stai...More data for this Ligand-Target Pair
TargetSignal peptide peptidase-like 2A(Mus musculus)
The Genomics Institute of The Novartis Research Foundation
Curated by ChEMBL
The Genomics Institute of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 137nMAssay Description:Inhibition of human ERG expressed in HEK293 cells assessed as decrease in peak tail current amplitude by path clamp methodMore data for this Ligand-Target Pair
TargetSignal peptide peptidase-like 2A(Mus musculus)
The Genomics Institute of The Novartis Research Foundation
Curated by ChEMBL
The Genomics Institute of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 180nMAssay Description:Inhibition of mouse SPPL2a expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 77 residues) NLS as substrate after 24 hrs by Hoechst stai...More data for this Ligand-Target Pair