BDBM50267863 (4Z)-5-Bromo-4-{[(3-hydroxy-4-methoxybenzyl)amino]methylene}-isoquinoline-1,3(2H,4H)-dione::CHEMBL489039

SMILES COc1ccc(CNC=C2C(=O)NC(=O)c3cccc(Br)c23)cc1O

InChI Key InChIKey=CSOPPVQBDUVTEY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50267863   

TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267863((4Z)-5-Bromo-4-{[(3-hydroxy-4-methoxybenzyl)amino]...)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin) assessed as inhibition of retinoblastoma susceptibility gene product phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267863((4Z)-5-Bromo-4-{[(3-hydroxy-4-methoxybenzyl)amino]...)
Affinity DataIC50:  940nMAssay Description:Inhibition of CDK4/Cyclin D1 (unknown origin) assessed as inhibition of retinoblastoma susceptibility gene product phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267863((4Z)-5-Bromo-4-{[(3-hydroxy-4-methoxybenzyl)amino]...)
Affinity DataIC50:  8.10E+3nMAssay Description:Inhibition of CDK1/Cyclin B1 (unknown origin) assessed as inhibition of retinoblastoma susceptibility gene product phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed