BDBM50268018 CHEMBL4096439
SMILES COc1n[nH]c2ncc(cc12)C#Cc1c(F)ccc(NS(=O)(=O)c2cccc(Cl)c2)c1F
InChI Key InChIKey=NEDXWYOBFJNWEA-UHFFFAOYSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 50268018
TargetMitogen-activated protein kinase kinase kinase 20(Homo sapiens (Human))
University Of Macau
Curated by ChEMBL
University Of Macau
Curated by ChEMBL
Affinity DataIC50: 4.20nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human full-length ZAK expressed in baculovirus infected Sf9 insect cells using MBP as substrate after...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 20(Homo sapiens (Human))
University Of Macau
Curated by ChEMBL
University Of Macau
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human full-length ZAK expressed in baculovirus infected Sf9 insect cells using MBP as substrate after...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of recombinant human B-RAF V600E mutant using Ser/Thr3 as substrate after 1 hr by FRET-based Z'-Lyte assayMore data for this Ligand-Target Pair
Affinity DataIC50: >6.00E+3nMAssay Description:Inhibition of wild type GST-tagged recombinant human full-length B-RAF expressed in baculovirus expression system using Ser/Thr3 as substrate after 1...More data for this Ligand-Target Pair