BDBM50271428 CHEMBL4128967::US11225469, Compound 298

SMILES C[C@@H]1CN(CCN1Cc1ccc(cc1)C(F)(F)F)C(=S)Nc1cc(C)cc(C)n1

InChI Key InChIKey=OLXIOSRXCGIVKZ-MRXNPFEDSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50271428   

TargetD-3-phosphoglycerate dehydrogenase(Homo sapiens (Human))
Whitehead Institute For Biomedical Research

US Patent
LigandPNGBDBM50271428(CHEMBL4128967 | US11225469, Compound 298)
Affinity DataIC50: <5.00E+3nMAssay Description:PHGDH assay buffer contained 50 mM TEA pH 8.0, 10 mM MgCl2, 0.05% BSA, and 0.01% Tween-20. PHGDH enzyme buffer consisted of assay buffer with 20 nM P...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetD-3-phosphoglycerate dehydrogenase(Homo sapiens (Human))
Whitehead Institute For Biomedical Research

US Patent
LigandPNGBDBM50271428(CHEMBL4128967 | US11225469, Compound 298)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of N-terminal His6-tagged human liver PHGDH expressed in Escherichia coli Rosetta (DE3)pLysS using 3-phosphoglycerate as substrate after 2...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed