BDBM50277281 4-(pyridin-4-ylmethylamino)-N-(3-(trifluoromethyl)phenyl)isothiazole-3-carboxamide::CHEMBL515880

SMILES FC(F)(F)c1cccc(NC(=O)c2nscc2NCc2ccncc2)c1

InChI Key InChIKey=QTSMTVDWAMIJBE-UHFFFAOYSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50277281   

TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Decode

Curated by ChEMBL
LigandPNGBDBM50277281(4-(pyridin-4-ylmethylamino)-N-(3-(trifluoromethyl)...)
Affinity DataKi:  130nMAssay Description:Inhibition of VEGFR2 (unknown origin) at IC90 concentration by ATP based competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Decode

Curated by ChEMBL
LigandPNGBDBM50277281(4-(pyridin-4-ylmethylamino)-N-(3-(trifluoromethyl)...)
Affinity DataKi:  160nMAssay Description:Inhibition of VEGFR2 (unknown origin) at IC50 concentration by ATP based competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Decode

Curated by ChEMBL
LigandPNGBDBM50277281(4-(pyridin-4-ylmethylamino)-N-(3-(trifluoromethyl)...)
Affinity DataIC50:  41nMAssay Description:Inhibition of VEGFR2 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Decode

Curated by ChEMBL
LigandPNGBDBM50277281(4-(pyridin-4-ylmethylamino)-N-(3-(trifluoromethyl)...)
Affinity DataIC50:  170nMAssay Description:Inhibition of VEGFR1 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Decode

Curated by ChEMBL
LigandPNGBDBM50277281(4-(pyridin-4-ylmethylamino)-N-(3-(trifluoromethyl)...)
Affinity DataIC50:  54nMAssay Description:Inhibition of VEGFR2 (unknown origin) expressed in HEK293 cells assessed as inhibition of receptor phosphorylation by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed