BDBM50277363 CHEMBL475510::N-(3-tert-butylphenyl)-4-(pyridin-4-ylmethylamino)isothiazole-3-carboxamide

SMILES CC(C)(C)c1cccc(NC(=O)c2nscc2NCc2ccncc2)c1

InChI Key InChIKey=ZMVIIRCGNJMLDL-UHFFFAOYSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50277363   

TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Decode

Curated by ChEMBL
LigandPNGBDBM50277363(CHEMBL475510 | N-(3-tert-butylphenyl)-4-(pyridin-4...)
Affinity DataKi:  120nMAssay Description:Inhibition of VEGFR2 (unknown origin) at IC90 concentration by ATP based competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Decode

Curated by ChEMBL
LigandPNGBDBM50277363(CHEMBL475510 | N-(3-tert-butylphenyl)-4-(pyridin-4...)
Affinity DataKi:  130nMAssay Description:Inhibition of VEGFR2 (unknown origin) at IC50 concentration by ATP based competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Decode

Curated by ChEMBL
LigandPNGBDBM50277363(CHEMBL475510 | N-(3-tert-butylphenyl)-4-(pyridin-4...)
Affinity DataIC50:  35nMAssay Description:Inhibition of VEGFR2 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Decode

Curated by ChEMBL
LigandPNGBDBM50277363(CHEMBL475510 | N-(3-tert-butylphenyl)-4-(pyridin-4...)
Affinity DataIC50:  310nMAssay Description:Inhibition of VEGFR1 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Decode

Curated by ChEMBL
LigandPNGBDBM50277363(CHEMBL475510 | N-(3-tert-butylphenyl)-4-(pyridin-4...)
Affinity DataIC50:  82nMAssay Description:Inhibition of VEGFR2 (unknown origin) expressed in HEK293 cells assessed as inhibition of receptor phosphorylation by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed