BDBM50278277 CHEMBL4169910::US11352322, Compound 28
SMILES ONC(=O)c1ccc(CNC2CC2c2ccccc2)cc1
InChI Key InChIKey=BWTYCKXFSJVJTA-UHFFFAOYSA-N
Data 7 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 7 hits for monomerid = 50278277
Affinity DataIC50: 1.44E+3nMAssay Description:Inhibition of TNF-alpha release was determined in LPS-stimulated human whole blood assayMore data for this Ligand-Target Pair
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Xinxiang Medical University
Curated by ChEMBL
Xinxiang Medical University
Curated by ChEMBL
Affinity DataIC50: 4.09E+3nMAssay Description:Inhibition of recombinant LSD1 (157 to 852 amino acids) (unknown origin) expressed in Escherichia coli BL21(DE) using H3K4me2 substrate by amplex red...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Xinxiang Medical University
Curated by ChEMBL
Xinxiang Medical University
Curated by ChEMBL
Affinity DataIC50: 4.58E+4nMAssay Description:Inhibition of MAOA (unknown origin) using beetle luciferin as substrate by MAO-Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 264nMAssay Description:Histone deacetylase assay was done as per manufacturer's instructions. Briefly, assay buffer, 200 uM HDAC substrate (fluorogenic HDAC acetylated ...More data for this Ligand-Target Pair
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of C-terminal His-tagged full length human HDAC2 expressed in baculovirus expression system using Ac-peptide substrate incubated for 15 mi...More data for this Ligand-Target Pair
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Xinxiang Medical University
Curated by ChEMBL
Xinxiang Medical University
Curated by ChEMBL
Affinity DataIC50: 23nMAssay Description:LSD1 enzyme was produced in house. Tranylcypromine (TCP), LSD1 inhibitor was procured from Selleckchem. LSD1 enzyme, TCP and Biotinylated peptide sub...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Xinxiang Medical University
Curated by ChEMBL
Xinxiang Medical University
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of MAOB (unknown origin) using beetle luciferin as substrate by MAO-Glo assayMore data for this Ligand-Target Pair