BDBM50278564 CHEMBL471036::Litoxetine::US9511061, Compound A

SMILES C(OC1CCNCC1)c1ccc2ccccc2c1

InChI Key InChIKey=MJJDYOLPMGIWND-UHFFFAOYSA-N

Data  6 KI  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50278564   

Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Ixaltis

US Patent
LigandPNGBDBM50278564(CHEMBL471036 | Litoxetine | US9511061, Compound A)
Affinity DataKi:  200nM IC50:  250nMAssay Description:The affinity of the compound A was evaluated in vitro on 8 cloned human serotoninergic receptors by measuring the specific binding of the ligands to ...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Ixaltis

US Patent
LigandPNGBDBM50278564(CHEMBL471036 | Litoxetine | US9511061, Compound A)
Affinity DataKi:  620nM IC50:  1.00E+3nMAssay Description:The affinity of the compound A was evaluated in vitro on 8 cloned human serotoninergic receptors by measuring the specific binding of the ligands to ...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Ixaltis

US Patent
LigandPNGBDBM50278564(CHEMBL471036 | Litoxetine | US9511061, Compound A)
Affinity DataKi:  720nM IC50:  1.40E+3nMAssay Description:The affinity of the compound A was evaluated in vitro on 8 cloned human serotoninergic receptors by measuring the specific binding of the ligands to ...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Ixaltis

US Patent
LigandPNGBDBM50278564(CHEMBL471036 | Litoxetine | US9511061, Compound A)
Affinity DataKi:  980nM IC50:  1.00E+3nMAssay Description:The affinity of the compound A was evaluated in vitro on 8 cloned human serotoninergic receptors by measuring the specific binding of the ligands to ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetIsoform 5-HT4(E) of 5-hydroxytryptamine receptor 4 (H5-HT4(g))(Homo sapiens (Human))
Ixaltis

US Patent
LigandPNGBDBM50278564(CHEMBL471036 | Litoxetine | US9511061, Compound A)
Affinity DataKi:  1.60E+3nM IC50:  4.70E+3nMAssay Description:The affinity of the compound A was evaluated in vitro on 8 cloned human serotoninergic receptors by measuring the specific binding of the ligands to ...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Ixaltis

US Patent
LigandPNGBDBM50278564(CHEMBL471036 | Litoxetine | US9511061, Compound A)
Affinity DataKi:  2.60E+3nM IC50:  7.20E+3nMAssay Description:The affinity of the compound A was evaluated in vitro on 8 cloned human serotoninergic receptors by measuring the specific binding of the ligands to ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50278564(CHEMBL471036 | Litoxetine | US9511061, Compound A)
Affinity DataIC50:  6nMAssay Description:Inhibition of radiolabeled serotonin reuptake at human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50278564(CHEMBL471036 | Litoxetine | US9511061, Compound A)
Affinity DataIC50:  6.50E+3nMAssay Description:Inhibition of radiolabeled noradrenaline reuptake at human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50278564(CHEMBL471036 | Litoxetine | US9511061, Compound A)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of radiolabeled dopamine reuptake at human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50278564(CHEMBL471036 | Litoxetine | US9511061, Compound A)
Affinity DataIC50:  5.90nMAssay Description:Inhibition of serotonin reuptake at human serotonin transporter expressed in HEK293 cells after 5 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50278564(CHEMBL471036 | Litoxetine | US9511061, Compound A)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of noradrenaline reuptake at human noradrenaline transporter expressed in HEK293 cells after 15 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50278564(CHEMBL471036 | Litoxetine | US9511061, Compound A)
Affinity DataIC50:  6.70E+3nMAssay Description:Inhibition of dopamine reuptake at human dopamine transporter expressed in HEK293 cells after 5 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed