BDBM50278675 (+/-)-cis-6-((4-(2-(3-Fluorophenethylamino)-ethoxy)-pyrrolidin-3-yl)methyl)-4-methyl-pyridin-2-amine::6-{[(3S,4S)-4-(2-{[2-(3-fluorophenyl)ethyl]amino}ethoxy)pyrrolidin-3-yl]methyl}-4-methylpyridin-2-amine::CHEMBL1278038::CHEMBL469987

SMILES Cc1cc(N)nc(C[C@H]2CNC[C@H]2OCCNCCc2cccc(F)c2)c1

InChI Key InChIKey=NESZTSPBRDBHCW-FXAWDEMLSA-N

Data  10 KI  2 IC50

PDB links: 2 PDB IDs match this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50278675   

TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Vibrant Pharma

Curated by ChEMBL
LigandPNGBDBM50278675((+/-)-cis-6-((4-(2-(3-Fluorophenethylamino)-ethoxy...)
Affinity DataKi:  7nMAssay Description:Inhibition of rat nNOSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Vibrant Pharma

Curated by ChEMBL
LigandPNGBDBM50278675((+/-)-cis-6-((4-(2-(3-Fluorophenethylamino)-ethoxy...)
Affinity DataKi:  15nMAssay Description:Inhibition of rat recombinant nNOS expressed in Escherichia coli assessed as nitric oxide formation by hemoglobin capture assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetNitric oxide synthase, inducible(Mus musculus (mouse))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50278675((+/-)-cis-6-((4-(2-(3-Fluorophenethylamino)-ethoxy...)
Affinity DataKi:  15nMAssay Description:Inhibition of mouse recombinant iNOSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Vibrant Pharma

Curated by ChEMBL
LigandPNGBDBM50278675((+/-)-cis-6-((4-(2-(3-Fluorophenethylamino)-ethoxy...)
Affinity DataKi:  9.50E+3nMAssay Description:Inhibition of rat recombinant nNOSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetNitric oxide synthase, inducible(Mus musculus (mouse))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50278675((+/-)-cis-6-((4-(2-(3-Fluorophenethylamino)-ethoxy...)
Affinity DataKi:  9.50E+3nMAssay Description:Inhibition of mouse recombinant iNOS expressed in Escherichia coli assessed as nitric oxide formation by hemoglobin capture assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Bos taurus (bovine))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50278675((+/-)-cis-6-((4-(2-(3-Fluorophenethylamino)-ethoxy...)
Affinity DataKi:  3.10E+4nMAssay Description:Inhibition of bovine recombinant eNOS expressed in Escherichia coli assessed as nitric oxide formation by hemoglobin capture assayMore data for this Ligand-Target Pair
TargetNitric oxide synthase, endothelial(Bos taurus (bovine))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50278675((+/-)-cis-6-((4-(2-(3-Fluorophenethylamino)-ethoxy...)
Affinity DataKi:  3.10E+4nMAssay Description:Inhibition of bovine recombinant eNOSMore data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50278675((+/-)-cis-6-((4-(2-(3-Fluorophenethylamino)-ethoxy...)
Affinity DataKi:  1.16E+5nMAssay Description:Inhibition of mouse recombinant iNOSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Vibrant Pharma

Curated by ChEMBL
LigandPNGBDBM50278675((+/-)-cis-6-((4-(2-(3-Fluorophenethylamino)-ethoxy...)
Affinity DataKi:  7.50E+6nMAssay Description:Inhibition of rat recombinant nNOSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetNitric oxide synthase, endothelial(Bos taurus (bovine))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50278675((+/-)-cis-6-((4-(2-(3-Fluorophenethylamino)-ethoxy...)
Affinity DataKi:  2.62E+7nMAssay Description:Inhibition of bovine recombinant eNOSMore data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Vibrant Pharma

Curated by ChEMBL
LigandPNGBDBM50278675((+/-)-cis-6-((4-(2-(3-Fluorophenethylamino)-ethoxy...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of recombinant rat nNOS expressed in Escherichia coli by hemoglobin capture assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Vibrant Pharma

Curated by ChEMBL
LigandPNGBDBM50278675((+/-)-cis-6-((4-(2-(3-Fluorophenethylamino)-ethoxy...)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of rat nNOS expressed in HEK293T cells preincubated for 30 mins prior A23187-induced activation measured after 6 hrs by Griess assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB