BDBM50283046 (Z)-7-[(2S,3S,4S)-4-(Biphenyl-4-ylmethoxy)-2-pyridin-3-yl-tetrahydro-thiophen-3-yl]-hept-4-enoic acid::CHEMBL292331

SMILES OC(=O)CC\C=C/CC[C@H]1[C@@H](CS[C@@H]1c1cccnc1)OCc1ccc(cc1)-c1ccccc1

InChI Key InChIKey=SHRNOBNPOTZEAM-RMZINKPKSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50283046   

TargetThromboxane-A synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50283046((Z)-7-[(2S,3S,4S)-4-(Biphenyl-4-ylmethoxy)-2-pyrid...)
Affinity DataIC50:  13nMAssay Description:In vitro inhibition of thromboxane synthaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetThromboxane A2 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50283046((Z)-7-[(2S,3S,4S)-4-(Biphenyl-4-ylmethoxy)-2-pyrid...)
Affinity DataIC50:  46nMAssay Description:In vitro thromboxane receptor antagonist activity was determined by inhibition of U-46619 induced aggregation of washed human plateletsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetThromboxane A2 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50283046((Z)-7-[(2S,3S,4S)-4-(Biphenyl-4-ylmethoxy)-2-pyrid...)
Affinity DataIC50:  22nMAssay Description:In vitro thromboxane receptor antagonist activity was determined by inhibition of U-46619 induced aggregation of washed human plateletsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetThromboxane-A synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50283046((Z)-7-[(2S,3S,4S)-4-(Biphenyl-4-ylmethoxy)-2-pyrid...)
Affinity DataIC50:  10nMAssay Description:In vitro thromboxane receptor antagonist activity was determined by inhibition of U-46619 induced aggregation of washed human plateletsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetThromboxane A2 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50283046((Z)-7-[(2S,3S,4S)-4-(Biphenyl-4-ylmethoxy)-2-pyrid...)
Affinity DataIC50:  22nMAssay Description:In vitro thromboxane receptor antagonist activity was determined by inhibition of U-46619 induced aggregation of washed human plateletsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetThromboxane-A synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50283046((Z)-7-[(2S,3S,4S)-4-(Biphenyl-4-ylmethoxy)-2-pyrid...)
Affinity DataIC50:  13nMAssay Description:In vitro inhibition of thromboxane synthaseMore data for this Ligand-Target Pair
In DepthDetails Article