BDBM50287277 CHEMBL4170753::US10759787, Example 18::US11059811, Example 18

SMILES CCN(C1CCOCC1)c1cc2occc2c(C(=O)NCc2c(OC)cc(C)[nH]c2=O)c1C

InChI Key InChIKey=IBJQZJITWHHCOE-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50287277   

LigandPNGBDBM50287277(CHEMBL4170753 | US10759787, Example 18 | US1105981...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EZH2 [A677G](Homo sapiens (Human))
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM50287277(CHEMBL4170753 | US10759787, Example 18 | US1105981...)
Affinity DataIC50:  4nMAssay Description:The activity of EZH2 enzyme (with A677G mutant or Y641F mutant) was tested by the following method.The method was used to determine the inhibitory ef...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2 [Y641F](Homo sapiens (Human))
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM50287277(CHEMBL4170753 | US10759787, Example 18 | US1105981...)
Affinity DataIC50:  2.30nMAssay Description:The activity of EZH2 enzyme (with A677G mutant or Y641F mutant) was tested by the following method.The method was used to determine the inhibitory ef...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2 [A677G](Homo sapiens (Human))
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM50287277(CHEMBL4170753 | US10759787, Example 18 | US1105981...)
Affinity DataIC50:  4nMAssay Description:The activity of EZH2 enzyme (with A677G mutant or Y641F mutant) was tested by the following method.The method was used to determine the inhibitory ef...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2 [Y641F](Homo sapiens (Human))
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM50287277(CHEMBL4170753 | US10759787, Example 18 | US1105981...)
Affinity DataIC50:  2.30nMAssay Description:The activity of EZH2 enzyme (with A677G mutant or Y641F mutant) was tested by the following method.The method was used to determine the inhibitory ef...More data for this Ligand-Target Pair
In DepthDetails US Patent