BDBM50290967 1-{(5R,7S,8S)-8-[(2-Benzofuran-4-yl-acetyl)-methyl-amino]-1-oxa-spiro[4.5]dec-7-yl}-pyrrolidinium::2-Benzofuran-4-yl-N-methyl-N-((5R,7S,8S)-7-pyrrolidin-1-yl-1-oxa-spiro[4.5]dec-8-yl)-acetamide::CHEMBL318859::CI-977

SMILES CN([C@H]1CC[C@@]2(CCCO2)C[C@@H]1N1CCCC1)C(=O)Cc1cccc2occc12

InChI Key InChIKey=JMBYBVLCYODBJQ-HFMPRLQTSA-N

Data  5 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50290967   

TargetKappa-type opioid receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50290967(1-{(5R,7S,8S)-8-[(2-Benzofuran-4-yl-acetyl)-methyl...)
Affinity DataKi:  0.100nMAssay Description:Compound was evaluated for the inhibition of binding of [3H]-U-69,593 to cloned rat Opioid receptor kappa 1 expressed in CHO cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
TargetKappa-type opioid receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50290967(1-{(5R,7S,8S)-8-[(2-Benzofuran-4-yl-acetyl)-methyl...)
Affinity DataKi:  0.270nMAssay Description:Inhibitory activity against Opioid receptor kappa 1 in chinese Hamster Ovary (CHO) cell membranes was determined using [3H]U-69593 radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50290967(1-{(5R,7S,8S)-8-[(2-Benzofuran-4-yl-acetyl)-methyl...)
Affinity DataKi:  22nMAssay Description:Inhibitory activity against Opioid receptor mu 1 in chinese Hamster Ovary (CHO) cells membranes was determined using [3H]-DAMGO radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50290967(1-{(5R,7S,8S)-8-[(2-Benzofuran-4-yl-acetyl)-methyl...)
Affinity DataKi:  87nMAssay Description:Compound was evaluated for the inhibition of binding of [3H]-DAGO to rat brain mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetDelta-type opioid receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50290967(1-{(5R,7S,8S)-8-[(2-Benzofuran-4-yl-acetyl)-methyl...)
Affinity DataKi: >1.00E+3nMAssay Description:Inhibitory activity against Opioid receptor delta 1 in chinese Hamster Ovary (CHO) cell membranes was determined using [3H]naltrindole radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50290967(1-{(5R,7S,8S)-8-[(2-Benzofuran-4-yl-acetyl)-methyl...)
Affinity DataEC50:  3.30nMAssay Description:Inhibition of Opioid receptor kappa 1 as reduced contraction in electrically stimulated rabbit vas deferensMore data for this Ligand-Target Pair
In DepthDetails Article