BDBM50293532 1-(3-(5-(4-(aminomethyl)phenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl)-3-(2-fluoro-4-(trifluoromethyl)phenyl)urea::CHEMBL551024

SMILES NCc1ccc(cc1)-c1cnc2[nH]cc(-c3cccc(NC(=O)Nc4ccc(cc4F)C(F)(F)F)c3)c2c1

InChI Key InChIKey=RDNOLDWOMGZBPI-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50293532   

TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50293532(1-(3-(5-(4-(aminomethyl)phenyl)-1H-pyrrolo[2,3-b]p...)
Affinity DataIC50:  50nMAssay Description:Inhibition of GST-tagged human IGF1R expressed in Sf9-baculovirus systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50293532(1-(3-(5-(4-(aminomethyl)phenyl)-1H-pyrrolo[2,3-b]p...)
Affinity DataIC50:  32nMAssay Description:Inhibition of IKK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50293532(1-(3-(5-(4-(aminomethyl)phenyl)-1H-pyrrolo[2,3-b]p...)
Affinity DataIC50:  79nMAssay Description:Inhibition of IKK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50293532(1-(3-(5-(4-(aminomethyl)phenyl)-1H-pyrrolo[2,3-b]p...)
Affinity DataIC50:  80nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50293532(1-(3-(5-(4-(aminomethyl)phenyl)-1H-pyrrolo[2,3-b]p...)
Affinity DataIC50:  250nMAssay Description:Inhibition of JNK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50293532(1-(3-(5-(4-(aminomethyl)phenyl)-1H-pyrrolo[2,3-b]p...)
Affinity DataIC50:  40nMAssay Description:Inhibition of LYNMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50293532(1-(3-(5-(4-(aminomethyl)phenyl)-1H-pyrrolo[2,3-b]p...)
Affinity DataIC50:  79nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed