BDBM50293721 CHEMBL562551::N-(4-chloro-3-methoxyphenyl)picolinamide::cid_44191096

SMILES COc1cc(NC(=O)c2ccccn2)ccc1Cl

InChI Key InChIKey=ARYUXFNGXHNNDM-UHFFFAOYSA-N

Data  7 IC50  9 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50293721   

TargetMetabotropic glutamate receptor 1(RAT)
Vanderbilt Screening Center For Gpcrs, Ion Channels and Transporters

Curated by PubChem BioAssay
LigandPNGBDBM50293721(CHEMBL562551 | N-(4-chloro-3-methoxyphenyl)picolin...)
Affinity DataEC50:  2.34E+3nMAssay Description:Assigned Assay Grant Number: NS053536-01 Screening Center Name & PI: Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters, C. David W...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCytochrome P450 3A4(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50293721(CHEMBL562551 | N-(4-chloro-3-methoxyphenyl)picolin...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using 1-hydroxymidazolam as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 8(Rattus norvegicus (Rat))
Vanderbilt Screening Center For Gpcrs, Ion Channels and Transporters

Curated by PubChem BioAssay
LigandPNGBDBM50293721(CHEMBL562551 | N-(4-chloro-3-methoxyphenyl)picolin...)
Affinity DataEC50:  6.17E+3nMAssay Description:Assigned Assay Grant Number: NS053536-01 Screening Center Name & PI: Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters, C. David W...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetMetabotropic glutamate receptor 7(Rattus norvegicus (Rat))
Vanderbilt Screening Center For Gpcrs, Ion Channels and Transporters

Curated by PubChem BioAssay
LigandPNGBDBM50293721(CHEMBL562551 | N-(4-chloro-3-methoxyphenyl)picolin...)
Affinity DataEC50:  4.45E+5nMAssay Description:Assigned Assay Grant Number: NS053536-01 Screening Center Name & PI: Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters, C. David W...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetMetabotropic glutamate receptor 4 [Q124R](Rattus norvegicus)
Vanderbilt Screening Center For Gpcrs, Ion Channels and Transporters

Curated by PubChem BioAssay
LigandPNGBDBM50293721(CHEMBL562551 | N-(4-chloro-3-methoxyphenyl)picolin...)
Affinity DataEC50:  107nMAssay Description:Assay Provider: Colleen Niswender Assay Provider Affiliation: Vanderbilt University The primary pathophysiological change giving rise to the symptoms...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Vanderbilt Screening Center For Gpcrs, Ion Channels and Transporters

Curated by PubChem BioAssay
LigandPNGBDBM50293721(CHEMBL562551 | N-(4-chloro-3-methoxyphenyl)picolin...)
Affinity DataEC50:  2.42E+3nMAssay Description:Assigned Assay Grant Number: NS053536-01 Screening Center Name & PI: Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters, C. David W...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetMetabotropic glutamate receptor 4(Rattus norvegicus (Rat))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50293721(CHEMBL562551 | N-(4-chloro-3-methoxyphenyl)picolin...)
Affinity DataIC50:  13nMAssay Description:Displacement of [3H]ML128 from rat mGlu4 receptor expressed in CHO cells after 30 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Rattus norvegicus (Rat))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50293721(CHEMBL562551 | N-(4-chloro-3-methoxyphenyl)picolin...)
Affinity DataIC50:  13nMAssay Description:Displacement of [3H]ML128 from rat mGlu4 receptor expressed in CHO cells after 30 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50293721(CHEMBL562551 | N-(4-chloro-3-methoxyphenyl)picolin...)
Affinity DataIC50:  5.10nMAssay Description:Displacement of [3H]N-(4-chloro-3-methoxyphenyl)picolinamide from human mGlu4 receptor expressed in CHO cell membranes incubated for 30 mins by liqui...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50293721(CHEMBL562551 | N-(4-chloro-3-methoxyphenyl)picolin...)
Affinity DataIC50:  5.10nMAssay Description:Displacement of [3H]N-(4-chloro-3-methoxyphenyl)picolinamide from human mGlu4 receptor expressed in CHO cell membranes incubated for 30 mins by liqui...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Rattus norvegicus (Rat))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50293721(CHEMBL562551 | N-(4-chloro-3-methoxyphenyl)picolin...)
Affinity DataEC50:  110nMAssay Description:Activity at rat mGluR4 receptor expressed in HEK293 cells assessed as effect on thallium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50293721(CHEMBL562551 | N-(4-chloro-3-methoxyphenyl)picolin...)
Affinity DataEC50:  240nMAssay Description:Activity at human mGluR4 receptor expressed in CHO cells assessed as effect on calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50293721(CHEMBL562551 | N-(4-chloro-3-methoxyphenyl)picolin...)
Affinity DataEC50:  240nMAssay Description:Positive allosteric modulation of human mGlu4 receptor expressed in BHK cells assessed as potentiation of glutamate-induced calcium mobilization afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50293721(CHEMBL562551 | N-(4-chloro-3-methoxyphenyl)picolin...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using 4-hydroxydiclofenac as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50293721(CHEMBL562551 | N-(4-chloro-3-methoxyphenyl)picolin...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextrophan tartarate as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50293721(CHEMBL562551 | N-(4-chloro-3-methoxyphenyl)picolin...)
Affinity DataEC50:  239nMAssay Description:Assay Provider: Colleen Niswender Assay Provider Affiliation: Vanderbilt University The primary pathophysiological change giving rise to the symptoms...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay