BDBM50293902 1-{4-methyl-3-[2-methyl-4-(2-methyl-2H-pyrazol-3-yl)-quinolin-8-yloxymethyl]-pyridin-2-ylmethyl}-3-trifluoromethyl-1H-pyridin-2-one::CHEMBL559825

SMILES Cc1cc(-c2ccnn2C)c2cccc(OCc3c(C)ccnc3Cn3cccc(c3=O)C(F)(F)F)c2n1

InChI Key InChIKey=MDGWFKBCHGOIRO-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50293902   

TargetB2 bradykinin receptor(Homo sapiens (Human))
Jerini

Curated by ChEMBL
LigandPNGBDBM50293902(1-{4-methyl-3-[2-methyl-4-(2-methyl-2H-pyrazol-3-y...)
Affinity DataIC50:  0.540nMAssay Description:Antagonist activity at B2 receptor in human HF15 cells assessed as inhibition of bradykinin-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Jerini

Curated by ChEMBL
LigandPNGBDBM50293902(1-{4-methyl-3-[2-methyl-4-(2-methyl-2H-pyrazol-3-y...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of human CYP2C19 by microtiter plate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Jerini

Curated by ChEMBL
LigandPNGBDBM50293902(1-{4-methyl-3-[2-methyl-4-(2-methyl-2H-pyrazol-3-y...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of human CYP3A4 by microtiter plate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Jerini

Curated by ChEMBL
LigandPNGBDBM50293902(1-{4-methyl-3-[2-methyl-4-(2-methyl-2H-pyrazol-3-y...)
Affinity DataIC50:  8.80nMAssay Description:Displacement of [3H]bradykinin from human recombinant B2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed