BDBM50295369 (2R)-4-(4-(4-Fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazin-1-ylsulfonyl)benzonitrile::CHEMBL551186

SMILES C[C@@H]1CN(CCN1S(=O)(=O)c1ccc(cc1)C#N)c1ccc(F)cc1C(F)(F)F

InChI Key InChIKey=HKSORBYDKKUFBK-CYBMUJFWSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50295369   

Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295369((2R)-4-(4-(4-Fluoro-2-(trifluoromethyl)phenyl)-2-m...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human 11betaHSD1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295369((2R)-4-(4-(4-Fluoro-2-(trifluoromethyl)phenyl)-2-m...)
Affinity DataIC50:  467nMAssay Description:Inhibition of mouse 11betaHSD1 expressed in CHO cells in presence of 10 % (v/v) human serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295369((2R)-4-(4-(4-Fluoro-2-(trifluoromethyl)phenyl)-2-m...)
Affinity DataIC50:  636nMAssay Description:Inhibition of mouse 11betaHSD1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed