BDBM50296249 (1R,2S,3S,5S)-methyl 8-(4-fluorobut-2-ynyl)-3-p-tolyl-8-azabicyclo[3.2.1]octane-2-carboxylate::CHEMBL562115

SMILES COC(=O)[C@@H]1[C@H]2CC[C@@H](C[C@@H]1c1ccc(C)cc1)N2CC#CCF

InChI Key InChIKey=UTLIGDFWNZZYCH-MANSERQUSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50296249   

TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Brookhaven National Laboratory

Curated by ChEMBL
LigandPNGBDBM50296249((1R,2S,3S,5S)-methyl 8-(4-fluorobut-2-ynyl)-3-p-to...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM50296249((1R,2S,3S,5S)-methyl 8-(4-fluorobut-2-ynyl)-3-p-to...)
Affinity DataIC50:  22.5nMAssay Description:Displacement of [3H]nisoxetine from human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM50296249((1R,2S,3S,5S)-methyl 8-(4-fluorobut-2-ynyl)-3-p-to...)
Affinity DataIC50:  31.0nMAssay Description:Displacement of [3H]NE from human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Brookhaven National Laboratory

Curated by ChEMBL
LigandPNGBDBM50296249((1R,2S,3S,5S)-methyl 8-(4-fluorobut-2-ynyl)-3-p-to...)
Affinity DataIC50:  3.26nMAssay Description:Displacement of [3H]DA from human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM50296249((1R,2S,3S,5S)-methyl 8-(4-fluorobut-2-ynyl)-3-p-to...)
Affinity DataIC50:  240nMAssay Description:Displacement of [3H]5-HT from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Brookhaven National Laboratory

Curated by ChEMBL
LigandPNGBDBM50296249((1R,2S,3S,5S)-methyl 8-(4-fluorobut-2-ynyl)-3-p-to...)
Affinity DataIC50:  1.93nMAssay Description:Displacement of [3H]WIN35,428 from human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM50296249((1R,2S,3S,5S)-methyl 8-(4-fluorobut-2-ynyl)-3-p-to...)
Affinity DataIC50:  108nMAssay Description:Displacement of [3H]citalopram from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed