BDBM50297875 2-(4-(3-(m-tolyloxy)propoxy)phenylthio)hexanoic acid::CHEMBL560484

SMILES CCCCC(Sc1ccc(OCCCOc2cccc(C)c2)cc1)C(O)=O

InChI Key InChIKey=RVWOTZLCSHAAGT-UHFFFAOYSA-N

Data  3 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50297875   

TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50297875(2-(4-(3-(m-tolyloxy)propoxy)phenylthio)hexanoic ac...)
Affinity DataEC50:  90nMAssay Description:Agonist activity at human PPARalpha expressed in african green monkey COS7 cells by Gal4 transactivation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50297875(2-(4-(3-(m-tolyloxy)propoxy)phenylthio)hexanoic ac...)
Affinity DataEC50:  3.00E+3nMAssay Description:Agonist activity at human PPARgamma expressed in african green monkey COS7 cells by Gal4 transactivation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Eberhard Karls University Tuebingen

Curated by ChEMBL
LigandPNGBDBM50297875(2-(4-(3-(m-tolyloxy)propoxy)phenylthio)hexanoic ac...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of mPGES-1 in human IL-1beta-stimulated A549 cell microsomes assessed as reduction of PGE2 formation from PGH2 after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Eberhard Karls University Tuebingen

Curated by ChEMBL
LigandPNGBDBM50297875(2-(4-(3-(m-tolyloxy)propoxy)phenylthio)hexanoic ac...)
Affinity DataIC50:  4.80E+3nMAssay Description:Inhibition of 5-lipoxygenase in A23187-stimulated human PMNL assessed as enzyme product formation preincubated 15 mins by RP-HPLC analysis in presenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Eberhard Karls University Tuebingen

Curated by ChEMBL
LigandPNGBDBM50297875(2-(4-(3-(m-tolyloxy)propoxy)phenylthio)hexanoic ac...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant 5-lipoxygenase expressed in Escherichia coli BL21 assessed as enzyme product formation using using arachidonic acid a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed