BDBM50299057 (R)-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3-methylbutanoic acid::CHEMBL575881

SMILES CC(C)ON([C@H](C(C)C)C(O)=O)S(=O)(=O)c1ccc(cc1)-c1ccccc1

InChI Key InChIKey=ABXUEPSHNXWTBZ-LJQANCHMSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50299057   

TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50299057((R)-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3-met...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of human recombinant pro-MMP14 catalytic domain after 4 hrs by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50299057((R)-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3-met...)
Affinity DataIC50:  2.40E+4nMAssay Description:Inhibition of para-aminophenylmercuric acetate-activated human recombinant pro-MMP9 catalytic domain after 4 hrs by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50299057((R)-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3-met...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of para-aminophenylmercuric acetate-activated human pro-MMP8 after 4 hrs by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50299057((R)-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3-met...)
Affinity DataIC50:  410nMAssay Description:Inhibition of autoactivated human pro-MMP12 after 4 hrs by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50299057((R)-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3-met...)
Affinity DataIC50:  5.40E+4nMAssay Description:Inhibition of trypsin activated human pro-MMP3 after 4 hrs by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-16(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50299057((R)-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3-met...)
Affinity DataIC50:  1.80E+4nMAssay Description:Inhibition of human recombinant pro-MMP16 catalytic domain after 4 hrs by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50299057((R)-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3-met...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of para-aminophenylmercuric acetate-activated human pro-MMP1 after 4 hrs by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50299057((R)-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3-met...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of para-aminophenylmercuric acetate-activated human recombinant pro-MMP2 catalytic domain after 4 hrs by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50299057((R)-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3-met...)
Affinity DataIC50:  7.90E+3nMAssay Description:Inhibition of para-aminophenylmercuric acetate-activated human pro-MMP13 after 4 hrs by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed