BDBM50299139 (R)-1-(4-(5-cyclopropyl-1H-pyrazol-3-ylamino)pyrrolo[1,2-f][1,2,4]triazin-2-yl)pyrrolidine-2-carboxamide::CHEMBL576179::US8592579, 6

SMILES NC(=O)[C@H]1CCCN1c1nc(Nc2cc([nH]n2)C2CC2)c2cccn2n1

InChI Key InChIKey=CGJRRFJDMMUHJW-GFCCVEGCSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50299139   

TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM50299139((R)-1-(4-(5-cyclopropyl-1H-pyrazol-3-ylamino)pyrro...)
Affinity DataIC50:  43nMpH: 7.4Assay Description:Kinase assay using IGF1-receptor.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1/G1/S-specific cyclin-E2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50299139((R)-1-(4-(5-cyclopropyl-1H-pyrazol-3-ylamino)pyrro...)
Affinity DataIC50:  24nMAssay Description:Inhibition of CDK2/Cyclin E after 60 mins by fluorescence electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM50299139((R)-1-(4-(5-cyclopropyl-1H-pyrazol-3-ylamino)pyrro...)
Affinity DataIC50:  199nMAssay Description:Inhibition of IGF1R after 60 mins by fluorescence electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed