BDBM50300074 1-(4-(4-morpholino-1-(2,2,2-trifluoroethyl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl)phenyl)-3-(pyridin-3-yl)urea::CHEMBL574680

SMILES FC(F)(F)Cn1ncc2c(nc(nc12)-c1ccc(NC(=O)Nc2cccnc2)cc1)N1CCOCC1

InChI Key InChIKey=ZUUDJPWGLNVXOA-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50300074   

TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300074(1-(4-(4-morpholino-1-(2,2,2-trifluoroethyl)-1H-pyr...)
Affinity DataIC50:  0.230nMAssay Description:Inhibition of Flag-tagged human mTOR by DELFIA methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50300074(1-(4-(4-morpholino-1-(2,2,2-trifluoroethyl)-1H-pyr...)
Affinity DataIC50:  10nMAssay Description:Inhibition of PI3Kalpha by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300074(1-(4-(4-morpholino-1-(2,2,2-trifluoroethyl)-1H-pyr...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of mTOR in HEK293 cells by DELFIA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50300074(1-(4-(4-morpholino-1-(2,2,2-trifluoroethyl)-1H-pyr...)
Affinity DataIC50:  10nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed