BDBM50302922 1-(4-bromo-3-methylphenyl)-2-(tert-butylamino)propan-1-one::2-(N-tert-Butylamino)-4'-bromo-5'-methylpropiophenone::CHEMBL565845

SMILES CC(NC(C)(C)C)C(=O)c1ccc(Br)c(C)c1

InChI Key InChIKey=PFEJBPNFLAFPKN-UHFFFAOYSA-N

Data  3 KI  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50302922   

TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50302922(1-(4-bromo-3-methylphenyl)-2-(tert-butylamino)prop...)
Affinity DataKi:  1.22E+3nMAssay Description:Displacement of [125I]RTI55 from cloned human SERT expressed in HEK293 cellsChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50302922(1-(4-bromo-3-methylphenyl)-2-(tert-butylamino)prop...)
Affinity DataKi:  1.74E+3nMAssay Description:Displacement of [125I]RTI55 from cloned human DAT expressed in HEK293 cellsChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50302922(1-(4-bromo-3-methylphenyl)-2-(tert-butylamino)prop...)
Affinity DataKi:  4.60E+3nMAssay Description:Displacement of [125I]RTI55 from cloned human NET expressed in HEK293 cellsChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50302922(1-(4-bromo-3-methylphenyl)-2-(tert-butylamino)prop...)
Affinity DataIC50:  7.25E+3nMAssay Description:Inhibition of [3H]norepinephrine uptake at human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50302922(1-(4-bromo-3-methylphenyl)-2-(tert-butylamino)prop...)
Affinity DataIC50:  32nMAssay Description:Antagonist activity at human alpha4beta2 nAChR receptor expressed in human SH-SY5Y cells assessed as inhibition of carbamylcholine-induced 86Rb+ effl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50302922(1-(4-bromo-3-methylphenyl)-2-(tert-butylamino)prop...)
Affinity DataIC50:  1.62E+3nMAssay Description:Inhibition of [3H]norepinephrine reuptake at human NET expressed in HEK293 cellsChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50302922(1-(4-bromo-3-methylphenyl)-2-(tert-butylamino)prop...)
Affinity DataIC50: >100nMAssay Description:Inhibition of [3H]serotonin uptake at human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50302922(1-(4-bromo-3-methylphenyl)-2-(tert-butylamino)prop...)
Affinity DataIC50:  950nMAssay Description:Inhibition of [3H]dopamine reuptake at human DAT expressed in HEK293 cellsChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50302922(1-(4-bromo-3-methylphenyl)-2-(tert-butylamino)prop...)
Affinity DataIC50:  473nMAssay Description:Inhibition of [3H]serotonin reuptake at human SERT expressed in HEK293 cellsChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50302922(1-(4-bromo-3-methylphenyl)-2-(tert-butylamino)prop...)
Affinity DataIC50:  2.81E+3nMAssay Description:Inhibition of [3H]dopamine uptake at human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed