BDBM50302986 6-(benzo[d][1,3]dioxol-5-yl)-N-(thiophen-2-ylmethyl)quinazolin-4-amine::CHEMBL567331

SMILES C(Nc1ncnc2ccc(cc12)-c1ccc2OCOc2c1)c1cccs1

InChI Key InChIKey=QFBOPHGXTBOQRN-UHFFFAOYSA-N

Data  12 IC50  7 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 50302986   

TargetDual specificity protein kinase CLK4(Homo sapiens (Human))
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50302986(6-(benzo[d][1,3]dioxol-5-yl)-N-(thiophen-2-ylmethy...)
Affinity DataIC50:  63nMAssay Description:Inhibition of Clk4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK4(Homo sapiens (Human))
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50302986(6-(benzo[d][1,3]dioxol-5-yl)-N-(thiophen-2-ylmethy...)
Affinity DataIC50:  50nMAssay Description:Inhibition of human CLK4More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50302986(6-(benzo[d][1,3]dioxol-5-yl)-N-(thiophen-2-ylmethy...)
Affinity DataKd:  680nMAssay Description:Binding affinity to Clk2 assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK3(Homo sapiens (Human))
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50302986(6-(benzo[d][1,3]dioxol-5-yl)-N-(thiophen-2-ylmethy...)
Affinity DataKd:  470nMAssay Description:Binding affinity to Clk3 assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK4(Homo sapiens (Human))
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50302986(6-(benzo[d][1,3]dioxol-5-yl)-N-(thiophen-2-ylmethy...)
Affinity DataKd:  50nMAssay Description:Binding affinity to Clk4 assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50302986(6-(benzo[d][1,3]dioxol-5-yl)-N-(thiophen-2-ylmethy...)
Affinity DataKd:  27nMAssay Description:Binding affinity to Dyrk1A assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Homo sapiens (Human))
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50302986(6-(benzo[d][1,3]dioxol-5-yl)-N-(thiophen-2-ylmethy...)
Affinity DataKd:  430nMAssay Description:Binding affinity to Dyrk1B assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50302986(6-(benzo[d][1,3]dioxol-5-yl)-N-(thiophen-2-ylmethy...)
Affinity DataKd:  230nMAssay Description:Binding affinity to EGFR assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Homo sapiens (Human))
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50302986(6-(benzo[d][1,3]dioxol-5-yl)-N-(thiophen-2-ylmethy...)
Affinity DataIC50:  697nMAssay Description:Inhibition of Dyrk1B kinase using ATP as substrate by 33P radiolabelled kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50302986(6-(benzo[d][1,3]dioxol-5-yl)-N-(thiophen-2-ylmethy...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of Clk2 kinase using ATP as substrate by 33P radiolabelled kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK3(Homo sapiens (Human))
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50302986(6-(benzo[d][1,3]dioxol-5-yl)-N-(thiophen-2-ylmethy...)
Affinity DataIC50:  6.94E+3nMAssay Description:Inhibition of Clk3 kinase using ATP as substrate by 33P radiolabelled kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50302986(6-(benzo[d][1,3]dioxol-5-yl)-N-(thiophen-2-ylmethy...)
Affinity DataIC50:  27nMAssay Description:Inhibition of Dyrk1A kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK4(Homo sapiens (Human))
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50302986(6-(benzo[d][1,3]dioxol-5-yl)-N-(thiophen-2-ylmethy...)
Affinity DataIC50:  39nMAssay Description:Inhibition of Clk4 kinase using ATP as substrate by 33P radiolabelled kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50302986(6-(benzo[d][1,3]dioxol-5-yl)-N-(thiophen-2-ylmethy...)
Affinity DataIC50:  59nMAssay Description:Inhibition of Clk1 kinase using ATP as substrate by 33P radiolabelled kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50302986(6-(benzo[d][1,3]dioxol-5-yl)-N-(thiophen-2-ylmethy...)
Affinity DataIC50:  62nMAssay Description:Inhibition of Dyrk1A kinase using ATP as substrate by 33P radiolabelled kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK3(Homo sapiens (Human))
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50302986(6-(benzo[d][1,3]dioxol-5-yl)-N-(thiophen-2-ylmethy...)
Affinity DataIC50:  470nMAssay Description:Inhibition of human CLK3More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50302986(6-(benzo[d][1,3]dioxol-5-yl)-N-(thiophen-2-ylmethy...)
Affinity DataIC50:  37nMAssay Description:Inhibition of human CLK1More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50302986(6-(benzo[d][1,3]dioxol-5-yl)-N-(thiophen-2-ylmethy...)
Affinity DataIC50:  680nMAssay Description:Inhibition of human CLK2More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50302986(6-(benzo[d][1,3]dioxol-5-yl)-N-(thiophen-2-ylmethy...)
Affinity DataKd:  37nMAssay Description:Binding affinity to Clk1 assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed