BDBM50303068 (S)-3-(6-(1-phenylethylamino)pyrimidin-4-yl)pyrazolo[1,5-a]pyrimidin-2-amine::CHEMBL576862

SMILES C[C@H](Nc1cc(ncn1)-c1c(N)nn2cccnc12)c1ccccc1

InChI Key InChIKey=AKILHWBTOZTDGA-LBPRGKRZSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50303068   

TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50303068((S)-3-(6-(1-phenylethylamino)pyrimidin-4-yl)pyrazo...)
Affinity DataIC50:  21nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50303068((S)-3-(6-(1-phenylethylamino)pyrimidin-4-yl)pyrazo...)
Affinity DataIC50:  1.80E+4nMAssay Description:Inhibition of JAK2-mediated STAT5 phosphorylation in GMCSF-stimulated human TF1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50303068((S)-3-(6-(1-phenylethylamino)pyrimidin-4-yl)pyrazo...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of JAK2-mediated STAT5 phosphorylation in GMCSF-stimulated human HT2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50303068((S)-3-(6-(1-phenylethylamino)pyrimidin-4-yl)pyrazo...)
Affinity DataIC50:  290nMAssay Description:Inhibition of JAK3 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed