BDBM50303221 6-(2,6-dichlorophenyl)-2-(4-iodophenylamino)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one::CHEMBL570175

SMILES Cn1c2nc(Nc3ccc(I)cc3)ncc2cc(-c2c(Cl)cccc2Cl)c1=O

InChI Key InChIKey=OKPRPWYLQUKXFE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50303221   

TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM50303221(6-(2,6-dichlorophenyl)-2-(4-iodophenylamino)-8-met...)
Affinity DataIC50:  341nMAssay Description:Inhibition of human recombinant SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM50303221(6-(2,6-dichlorophenyl)-2-(4-iodophenylamino)-8-met...)
Affinity DataIC50:  766nMAssay Description:Inhibition of human recombinant C-KitMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM50303221(6-(2,6-dichlorophenyl)-2-(4-iodophenylamino)-8-met...)
Affinity DataIC50:  13nMAssay Description:Inhibition of human recombinant AblMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM50303221(6-(2,6-dichlorophenyl)-2-(4-iodophenylamino)-8-met...)
Affinity DataIC50:  224nMAssay Description:Inhibition of human recombinant P38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed