BDBM50304351 6-methoxy-1-(3-methoxy-prop-1-ynyl)-2-methyl-1,2,3,4-tetrahydro-isoquinolin-7-ol::CHEMBL592963

SMILES COCC#CC1N(C)CCc2cc(OC)c(O)cc12

InChI Key InChIKey=BURMEHSWUGTTOX-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50304351   

TargetNAD-dependent protein deacetylase HST2(Saccharomyces cerevisiae)
Institute

Curated by ChEMBL
LigandPNGBDBM50304351(6-methoxy-1-(3-methoxy-prop-1-ynyl)-2-methyl-1,2,3...)
Affinity DataKi:  4.20E+4nMAssay Description:Mixed inhibition of yeast Hst2 using NAD+ substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase HST2(Saccharomyces cerevisiae)
Institute

Curated by ChEMBL
LigandPNGBDBM50304351(6-methoxy-1-(3-methoxy-prop-1-ynyl)-2-methyl-1,2,3...)
Affinity DataKi:  4.30E+4nMAssay Description:Noncompetitive inhibition of yeast Hst2 using Acetyl-lysine substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM50304351(6-methoxy-1-(3-methoxy-prop-1-ynyl)-2-methyl-1,2,3...)
Affinity DataIC50:  5.70E+5nMAssay Description:Inhibition of human full length SIRT1 expressed in DE3 cells by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase HST2(Saccharomyces cerevisiae)
Institute

Curated by ChEMBL
LigandPNGBDBM50304351(6-methoxy-1-(3-methoxy-prop-1-ynyl)-2-methyl-1,2,3...)
Affinity DataIC50:  1.30E+5nMAssay Description:Inhibition of yeast Hst2 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed