BDBM50306157 3-((S)-2-amino-3-(1H-indol-3-yl)propoxy)-5-(3-methyl-1H-pyrazolo[4,3-b]pyrazin-5-yl)-6-(2-methylfuran-3-yl)pyridin-2-amine::CHEMBL595944

SMILES Cc1n[nH]c2ncc(nc12)-c1cc(OC[C@@H](N)Cc2c[nH]c3ccccc23)c(N)nc1-c1ccoc1C

InChI Key InChIKey=CMPFTOKTVXYPFY-KRWDZBQOSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50306157   

TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50306157(3-((S)-2-amino-3-(1H-indol-3-yl)propoxy)-5-(3-meth...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human AKT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50306157(3-((S)-2-amino-3-(1H-indol-3-yl)propoxy)-5-(3-meth...)
Affinity DataIC50:  19nMAssay Description:Inhibition of human AKT2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50306157(3-((S)-2-amino-3-(1H-indol-3-yl)propoxy)-5-(3-meth...)
Affinity DataIC50:  1.04E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50306157(3-((S)-2-amino-3-(1H-indol-3-yl)propoxy)-5-(3-meth...)
Affinity DataIC50:  560nMAssay Description:Inhibition of GSK2beta phosphorylation in human BT474 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50306157(3-((S)-2-amino-3-(1H-indol-3-yl)propoxy)-5-(3-meth...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50306157(3-((S)-2-amino-3-(1H-indol-3-yl)propoxy)-5-(3-meth...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human AKT3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed