BDBM50309222 6,7-dichloro-4-(4-fluoro-3-(4-(2-methyl-2-(methylamino)propanoyl)piperazine-1-carbonyl)benzyl)pyrrolo[1,2-a]pyrazin-1(2H)-one::CHEMBL590791

SMILES CNC(C)(C)C(=O)N1CCN(CC1)C(=O)c1cc(Cc2c[nH]c(=O)c3cc(Cl)c(Cl)n23)ccc1F

InChI Key InChIKey=LVAOEBJMYZUGDP-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50309222   

TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309222(6,7-dichloro-4-(4-fluoro-3-(4-(2-methyl-2-(methyla...)
Affinity DataIC50:  2nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309222(6,7-dichloro-4-(4-fluoro-3-(4-(2-methyl-2-(methyla...)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309222(6,7-dichloro-4-(4-fluoro-3-(4-(2-methyl-2-(methyla...)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309222(6,7-dichloro-4-(4-fluoro-3-(4-(2-methyl-2-(methyla...)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of PARP1 by topcount microplate scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed