BDBM50313478 4-(3-(tert-butylamino)propyl)-6-(3-(trifluoromethyl)phenyl)pyrimidine-2-carbonitrile::CHEMBL1084402

SMILES CC(C)(C)NCCCc1cc(nc(n1)C#N)-c1cccc(c1)C(F)(F)F

InChI Key InChIKey=ADOJZMMSYUTJST-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50313478   

TargetCathepsin K(Homo sapiens (Human))
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313478(4-(3-(tert-butylamino)propyl)-6-(3-(trifluoromethy...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human recombinant cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313478(4-(3-(tert-butylamino)propyl)-6-(3-(trifluoromethy...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human recombinant cathepsin S by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313478(4-(3-(tert-butylamino)propyl)-6-(3-(trifluoromethy...)
Affinity DataIC50:  1.10E+3nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313478(4-(3-(tert-butylamino)propyl)-6-(3-(trifluoromethy...)
Affinity DataIC50:  6.46E+3nMAssay Description:Inhibition of human recombinant cathepsin B by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313478(4-(3-(tert-butylamino)propyl)-6-(3-(trifluoromethy...)
Affinity DataIC50:  9.77E+3nMAssay Description:Inhibition of human recombinant cathepsin L by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed