BDBM50313651 7-(3-(azetidin-1-ylmethyl)cyclobutyl)-5-(4-(benzyloxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine::CHEMBL1083527

SMILES Nc1ncnc2n(cc(-c3ccc(OCc4ccccc4)cc3)c12)[C@@H]1C[C@H](CN2CCC2)C1

InChI Key InChIKey=MJEHBQIPZHTMNZ-GRGXKFILSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50313651   

TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313651(7-(3-(azetidin-1-ylmethyl)cyclobutyl)-5-(4-(benzyl...)
Affinity DataEC50:  86nMAssay Description:Inhibition of IGF1R in human TC71 cells assessed as inhibition of Akt phosphorylation by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313651(7-(3-(azetidin-1-ylmethyl)cyclobutyl)-5-(4-(benzyl...)
Affinity DataIC50:  150nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313651(7-(3-(azetidin-1-ylmethyl)cyclobutyl)-5-(4-(benzyl...)
Affinity DataIC50:  140nMAssay Description:Inhibition of INSRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed