BDBM50314839 3'-(4-Chlorophenyl-1,2,3-triazol-1-yl)-3'-deoxy-beta-D-thymidine::CHEMBL1089867

SMILES Cc1cn([C@H]2C[C@@H]([C@@H](CO)O2)n2cc(nn2)-c2ccc(Cl)cc2)c(=O)[nH]c1=O

InChI Key InChIKey=WWMWBLWTLDFTOG-ARFHVFGLSA-N

Data  1 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50314839   

TargetThymidylate kinase(Mycobacterium tuberculosis)
Ghent University

Curated by ChEMBL
LigandPNGBDBM50314839(3'-(4-Chlorophenyl-1,2,3-triazol-1-yl)-3'-deoxy-be...)
Affinity DataKi:  2.10E+3nMAssay Description:Competitive inhibition of Mycobacterium tuberculosis TMPK by Lineweaver-Burk analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine kinase(Human herpesvirus 1 (strain SC16) (HHV-1) (Human h...)
Ghent University

Curated by ChEMBL
LigandPNGBDBM50314839(3'-(4-Chlorophenyl-1,2,3-triazol-1-yl)-3'-deoxy-be...)
Affinity DataIC50:  2.70E+4nMAssay Description:Inhibition of HSV1 thymidine kinase assessed as inhibition of [methyl-3H]dThd phosphorylation after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine kinase, cytosolic(Homo sapiens (Human))
Ghent University

Curated by ChEMBL
LigandPNGBDBM50314839(3'-(4-Chlorophenyl-1,2,3-triazol-1-yl)-3'-deoxy-be...)
Affinity DataIC50:  7.10E+4nMAssay Description:Inhibition of human recombinant cytosolic thymidine kinase 1 assessed as inhibition of [methyl-3H]dThd phosphorylation after 30 mins by scintillation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine kinase 2, mitochondrial(Homo sapiens (Human))
Ghent University

Curated by ChEMBL
LigandPNGBDBM50314839(3'-(4-Chlorophenyl-1,2,3-triazol-1-yl)-3'-deoxy-be...)
Affinity DataIC50:  46nMAssay Description:Inhibition of human recombinant mitochondrial thymidine kinase 2 assessed as inhibition of [methyl-3H]dThd phosphorylation after 30 mins by scintilla...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDeoxynucleoside kinase(Drosophila melanogaster)
Ghent University

Curated by ChEMBL
LigandPNGBDBM50314839(3'-(4-Chlorophenyl-1,2,3-triazol-1-yl)-3'-deoxy-be...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of Drosophila melanogaster multifunctional deoxynucleoside kinase assessed as inhibition of [methyl-3H]dThd phosphorylation after 30 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed