BDBM50314989 CHEMBL1092250::N-(3-Ethynylphenyl)-6,7-dimethoxyquinolin-4-amine
SMILES COc1cc2nccc(Nc3cccc(c3)C#C)c2cc1OC
InChI Key InChIKey=WMAOMQUWVSXRPR-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 50314989
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Chemical Genomics Centre Of The Max Planck Society
Curated by ChEMBL
Chemical Genomics Centre Of The Max Planck Society
Curated by ChEMBL
Affinity DataIC50: 19nMAssay Description:Inhibition of wild type EGFR by HTRF assayMore data for this Ligand-Target Pair
TargetCyclin-G-associated kinase(Homo sapiens (Human))
University Of North Carolina At Chapel Hill
Curated by ChEMBL
University Of North Carolina At Chapel Hill
Curated by ChEMBL
Affinity DataIC50: 500nMAssay Description:Inhibition of tracer 5 binding to human N-terminal nano luciferase-fused GAK expressed in HEK293 cells measured after 2 hrs by nanoBRET assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Chemical Genomics Centre Of The Max Planck Society
Curated by ChEMBL
Chemical Genomics Centre Of The Max Planck Society
Curated by ChEMBL
Affinity DataIC50: 42nMAssay Description:Inhibition of EGFR in human A431 cells assessed as reduction in EGF-stimulated EGFR autophosphorylation preincuabted for 90 mins followed by EGF-stim...More data for this Ligand-Target Pair
TargetCyclin-G-associated kinase(Homo sapiens (Human))
University Of North Carolina At Chapel Hill
Curated by ChEMBL
University Of North Carolina At Chapel Hill
Curated by ChEMBL
Affinity DataKd: 7.60nMAssay Description:Binding affinity to wild-type human partial length GAK (G13 to Y338 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Chemical Genomics Centre Of The Max Planck Society
Curated by ChEMBL
Chemical Genomics Centre Of The Max Planck Society
Curated by ChEMBL
Affinity DataKd: 0.270nMAssay Description:Binding affinity to wild-type human partial length EGFR (R669 to V1011 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair