BDBM50315657 2-(4-chloro-6-(naphthalen-2-ylamino)pyrimidin-2-ylthio)-2-(naphthalen-1-yl)acetic acid::CHEMBL1091523

SMILES OC(=O)C(Sc1nc(Cl)cc(Nc2ccc3ccccc3c2)n1)c1cccc2ccccc12

InChI Key InChIKey=FHLFDNGKWOUAFE-UHFFFAOYSA-N

Data  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50315657   

TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50315657(2-(4-chloro-6-(naphthalen-2-ylamino)pyrimidin-2-yl...)
Affinity DataEC50:  6.90E+3nMAssay Description:Transactivation of human PPARgamma LBD expressed in african green monkey Cos7 cells co-transfected with fused GAL4-DBD after 14 hrs by Dual-Glo Lucif...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50315657(2-(4-chloro-6-(naphthalen-2-ylamino)pyrimidin-2-yl...)
Affinity DataIC50:  2.90E+3nMAssay Description:Inhibition of human recombinant 5-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50315657(2-(4-chloro-6-(naphthalen-2-ylamino)pyrimidin-2-yl...)
Affinity DataIC50:  500nMAssay Description:Inhibition of 5-lipoxygenase in human PMNLMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50315657(2-(4-chloro-6-(naphthalen-2-ylamino)pyrimidin-2-yl...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of mPGES-1 expressed in LPS-stimulated human A549 cells mitochondrial fraction assessed as conversion of PGH2 to PGE2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed