BDBM50315666 2-(4-chloro-6-(3-phenylpropylamino)pyrimidin-2-ylthio)-2-(naphthalen-1-yl)acetic acid::CHEMBL1089826

SMILES OC(=O)C(Sc1nc(Cl)cc(NCCCc2ccccc2)n1)c1cccc2ccccc12

InChI Key InChIKey=MTEBXMPXGZSGGW-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50315666   

TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50315666(2-(4-chloro-6-(3-phenylpropylamino)pyrimidin-2-ylt...)
Affinity DataEC50:  8.90E+3nMAssay Description:Transactivation of human PPARgamma LBD expressed in african green monkey Cos7 cells co-transfected with fused GAL4-DBD after 14 hrs by Dual-Glo Lucif...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50315666(2-(4-chloro-6-(3-phenylpropylamino)pyrimidin-2-ylt...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of 5-lipoxygenase in human PMNLMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50315666(2-(4-chloro-6-(3-phenylpropylamino)pyrimidin-2-ylt...)
Affinity DataIC50:  6.10E+3nMAssay Description:Inhibition of mPGES-1 expressed in LPS-stimulated human A549 cells mitochondrial fraction assessed as conversion of PGH2 to PGE2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed