BDBM50316561 1-(2-chloro-4-fluorophenyl)-2,2,2-trifluoro-1-(1-(4-fluorophenyl)-1H-indazol-5-yl)ethanol::1-(3-CHLORO-4-FLUOROPHENYL)-2,2,2-TRIFLUORO-1-(1-(4-FLUOROPHENYL)-1H-INDAZOL-5-YL)ETHANOL (ENANTIOMERIC MIX)::1-(3-chloro-4-fluorophenyl)-2,2,2-trifluoro-1-(1-(4-fluorophenyl)-1H-indazol-5-yl)ethanol::CHEMBL1094231

SMILES OC(c1ccc(F)c(Cl)c1)(c1ccc2n(ncc2c1)-c1ccc(F)cc1)C(F)(F)F

InChI Key InChIKey=DAXGWLCLIPNRDH-UHFFFAOYSA-N

Data  3 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50316561   

TargetGlucocorticoid receptor(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50316561(1-(2-chloro-4-fluorophenyl)-2,2,2-trifluoro-1-(1-(...)
Affinity DataEC50:  93nMAssay Description:Agonist activity at glucocorticoid receptor in human fibroblast assessed as inhibition of IL-1-beta-induced IL6 production treated 1 hr before IL1-be...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50316561(1-(2-chloro-4-fluorophenyl)-2,2,2-trifluoro-1-(1-(...)
Affinity DataIC50:  117nMAssay Description:Binding affinity to human glucocorticoid receptor by fluorescence polariztion competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50316561(1-(2-chloro-4-fluorophenyl)-2,2,2-trifluoro-1-(1-(...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human ERG by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50316561(1-(2-chloro-4-fluorophenyl)-2,2,2-trifluoro-1-(1-(...)
Affinity DataEC50:  1.10E+3nMAssay Description:Agonist activity at glucocorticoid receptor in human MDA-kb2 cells transfected with MMTV-LUC assessed as induction of MMTV-LTR/promoter linked LUC ge...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50316561(1-(2-chloro-4-fluorophenyl)-2,2,2-trifluoro-1-(1-(...)
Affinity DataIC50:  117nMAssay Description:Binding affinity to human glucocorticoid receptor by fluorescence polariztion competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed