BDBM50317161 (2'Z,3'E)-5-Nitro-5'-hydroxy-indirubin-3'-oxime::CHEMBL1088704

SMILES Oc1ccc2[nH]c(c(N=[OH+])c2c1)-[c-]1c2cc(ccc2[nH]c1=O)[N+]([O-])=O

InChI Key InChIKey=AHIMCOQTGQUIII-UHFFFAOYSA-O

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50317161   

TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50317161((2'Z,3'E)-5-Nitro-5'-hydroxy-indirubin-3'-oxime | ...)
Affinity DataIC50:  13nMAssay Description:Inhibition of CDK1/cyclin B after 40 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50317161((2'Z,3'E)-5-Nitro-5'-hydroxy-indirubin-3'-oxime | ...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of CDK2/cyclin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50317161((2'Z,3'E)-5-Nitro-5'-hydroxy-indirubin-3'-oxime | ...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of recombinant TrKa preincubated for 15 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50317161((2'Z,3'E)-5-Nitro-5'-hydroxy-indirubin-3'-oxime | ...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of recombinant IKK-beta preincubated for 15 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50317161((2'Z,3'E)-5-Nitro-5'-hydroxy-indirubin-3'-oxime | ...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of recombinant auroraA preincubated for 15 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed