BDBM50317324 CHEMBL1087984::N-(4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenyl)-1-phenyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide::US8999982, Ref1

SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4C(F)(F)F)-c4ccccc4)cc3F)c2cc1OC

InChI Key InChIKey=XVUGJMRSDJSHFU-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50317324   

TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Lead Discovery Center

US Patent
LigandPNGBDBM50317324(CHEMBL1087984 | N-(4-(6,7-dimethoxyquinolin-4-ylox...)
Affinity DataIC50: >1.00E+4nMpH: 8.0Assay Description:The principle behind this assay is based upon the binding and displacement of an Alexa Fluor 647-labeled tracer to the kinase of interest. Binding of...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50317324(CHEMBL1087984 | N-(4-(6,7-dimethoxyquinolin-4-ylox...)
Affinity DataIC50:  80nMAssay Description:Inhibition of TPR-tagged RON catalytic domain expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50317324(CHEMBL1087984 | N-(4-(6,7-dimethoxyquinolin-4-ylox...)
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Chemrf Laboratories

Curated by ChEMBL
LigandPNGBDBM50317324(CHEMBL1087984 | N-(4-(6,7-dimethoxyquinolin-4-ylox...)
Affinity DataIC50:  1.06E+3nMAssay Description:Inhibition of phosphorylation of c-Met in human MKN45 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Chemrf Laboratories

Curated by ChEMBL
LigandPNGBDBM50317324(CHEMBL1087984 | N-(4-(6,7-dimethoxyquinolin-4-ylox...)
Affinity DataIC50:  200nMAssay Description:Inhibition of c-MetMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50317324(CHEMBL1087984 | N-(4-(6,7-dimethoxyquinolin-4-ylox...)
Affinity DataIC50:  16nMAssay Description:Inhibition of RON (unknown origin) transfected in 293T cells assessed as autophosporylated level by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed