BDBM50317324 CHEMBL1087984::N-(4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenyl)-1-phenyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide::US8999982, Ref1
SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4C(F)(F)F)-c4ccccc4)cc3F)c2cc1OC
InChI Key InChIKey=XVUGJMRSDJSHFU-UHFFFAOYSA-N
Data 6 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 50317324
Affinity DataIC50: >1.00E+4nMpH: 8.0Assay Description:The principle behind this assay is based upon the binding and displacement of an Alexa Fluor 647-labeled tracer to the kinase of interest. Binding of...More data for this Ligand-Target Pair
Affinity DataIC50: 80nMAssay Description:Inhibition of TPR-tagged RON catalytic domain expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Methylgene
Curated by ChEMBL
Methylgene
Curated by ChEMBL
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
Affinity DataIC50: 1.06E+3nMAssay Description:Inhibition of phosphorylation of c-Met in human MKN45 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Inhibition of RON (unknown origin) transfected in 293T cells assessed as autophosporylated level by ELISAMore data for this Ligand-Target Pair