BDBM50318183 CHEMBL1095465::N4-(3-bromophenyl)-6-(2,5-dimethoxybenzyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine

SMILES COc1ccc(OC)c(Cc2cc3c(Nc4cccc(Br)c4)nc(N)nc3[nH]2)c1

InChI Key InChIKey=SMXAGMTVWRGJRI-UHFFFAOYSA-N

Data  15 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50318183   

TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50318183(CHEMBL1095465 | N4-(3-bromophenyl)-6-(2,5-dimethox...)
Affinity DataIC50:  600nMAssay Description:Inhibition of VEGFR2 phosphorylation in human U251 cells after 10 mins by FLISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50318183(CHEMBL1095465 | N4-(3-bromophenyl)-6-(2,5-dimethox...)
Affinity DataIC50:  8.92E+3nMAssay Description:Inhibition of PDGFRbeta expressed in human A431 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50318183(CHEMBL1095465 | N4-(3-bromophenyl)-6-(2,5-dimethox...)
Affinity DataIC50:  3.11E+4nMAssay Description:Inhibition of VEGFR1 phosphorylation in human A498 cells after 10 mins by FLISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50318183(CHEMBL1095465 | N4-(3-bromophenyl)-6-(2,5-dimethox...)
Affinity DataIC50:  8.90E+3nMAssay Description:Inhibition of PDGFRbeta phosphorylation in human SF539 cells after 10 mins by FLISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50318183(CHEMBL1095465 | N4-(3-bromophenyl)-6-(2,5-dimethox...)
Affinity DataIC50:  240nMAssay Description:Inhibition of EGFR tyrosine kinase activity in EGF-stimulated human A431 cells after 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50318183(CHEMBL1095465 | N4-(3-bromophenyl)-6-(2,5-dimethox...)
Affinity DataIC50:  4.54E+4nMAssay Description:Inhibition of VEGFR2 tyrosine kinase activity in VEGF-stimulated human U251 cells after 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50318183(CHEMBL1095465 | N4-(3-bromophenyl)-6-(2,5-dimethox...)
Affinity DataIC50:  4.59E+4nMAssay Description:Inhibition of VEGFR1 tyrosine kinase activity in VEGF-stimulated human A498 cells after 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50318183(CHEMBL1095465 | N4-(3-bromophenyl)-6-(2,5-dimethox...)
Affinity DataIC50: >3.00E+5nMAssay Description:Inhibition of PDGFRbeta tyrosine kinase activity in PDGF-BB-stimulated human SF-539 cells after 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50318183(CHEMBL1095465 | N4-(3-bromophenyl)-6-(2,5-dimethox...)
Affinity DataIC50:  1.26E+4nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50318183(CHEMBL1095465 | N4-(3-bromophenyl)-6-(2,5-dimethox...)
Affinity DataIC50:  3.11E+4nMAssay Description:Inhibition of VEGFR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50318183(CHEMBL1095465 | N4-(3-bromophenyl)-6-(2,5-dimethox...)
Affinity DataIC50:  620nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50318183(CHEMBL1095465 | N4-(3-bromophenyl)-6-(2,5-dimethox...)
Affinity DataIC50:  8.92E+3nMAssay Description:Inhibition of PDGFRbetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50318183(CHEMBL1095465 | N4-(3-bromophenyl)-6-(2,5-dimethox...)
Affinity DataIC50:  1.26E+4nMAssay Description:Inhibition of EGFR expressed in human A431 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50318183(CHEMBL1095465 | N4-(3-bromophenyl)-6-(2,5-dimethox...)
Affinity DataIC50:  620nMAssay Description:Inhibition of VEGFR2 expressed in human A431 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50318183(CHEMBL1095465 | N4-(3-bromophenyl)-6-(2,5-dimethox...)
Affinity DataIC50:  1.26E+4nMAssay Description:Inhibition of EGFR phosphorylation in human A431 cells after 10 mins by FLISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed