BDBM50319586 (2R)-(4-[3-(2,6-Difluorophenyl)-2,2-dioxido-2,1,3-benzothiadiazol-1(3H)-yl]-1-(methylamino)butan-2-ol::CHEMBL1083428

SMILES CNC[C@H](O)CCN1c2ccccc2N(c2c(F)cccc2F)S1(=O)=O

InChI Key InChIKey=KCQQWPYAESYXHU-GFCCVEGCSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50319586   

TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319586((2R)-(4-[3-(2,6-Difluorophenyl)-2,2-dioxido-2,1,3-...)
Affinity DataIC50:  9nMAssay Description:Inhibition of human NET-mediated norepinephrine uptake in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319586((2R)-(4-[3-(2,6-Difluorophenyl)-2,2-dioxido-2,1,3-...)
Affinity DataIC50:  5.50E+3nMAssay Description:Displacement of [3H]WIN35428 from human recombinant DAT expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319586((2R)-(4-[3-(2,6-Difluorophenyl)-2,2-dioxido-2,1,3-...)
Affinity DataIC50:  6nMAssay Description:Displacement of [3H]nisoxetine from human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed