BDBM50320491 2-(3-CYANO-4-ISOBUTOXY-PHENYL)-4-METHYL-5-THIAZOLE-CARBOXYLIC ACID::CHEMBL1164729::FEBUXOSTAT::US11744839, Compound of formula 5

SMILES CC(C)COc1ccc(cc1C#N)-c1nc(C)c(s1)C(O)=O

InChI Key InChIKey=BQSJTQLCZDPROO-UHFFFAOYSA-N

Data  6 KI  28 IC50  3 Kd  1 ITC

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50320491   

TargetFlavin reductase (NADPH)(Homo sapiens)
Korea Basic Science Institute

US Patent
LigandPNGBDBM50320491(2-(3-CYANO-4-ISOBUTOXY-PHENYL)-4-METHYL-5-THIAZOLE...)
Affinity DataKd:  1.63E+3nMAssay Description:An enzyme activity assay for BLVRB was conducted. Since BLVRB catalyzes the NAD(P)H dependent readuction of FMN, changes in the NAD(P)H concentration...More data for this Ligand-Target Pair

Activity Spreadsheet -- ITC Data from BindingDB

Found 1 hit for monomerid = 50320491   

CellFlavin reductase (NADPH)(Homo sapiens)
Korea Basic Science Institute

US Patent
SyringePNGBDBM50320491(2-(3-CYANO-4-ISOBUTOXY-PHENYL)-4-METHYL-5-THIAZOLE...)
ITC DataΔG°: -7.91kcal/mole −TΔS°: -2.14kcal/mole ΔH°: -5.76kcal/mole logk: 6.30E+5
T: 25.00°C