BDBM50320996 6-(3-((S)-1-methoxypropan-2-yloxy)-5-((S)-1-phenylpropan-2-yloxy)benzamido)nicotinic acid::CHEMBL205627

SMILES COC[C@H](C)Oc1cc(O[C@@H](C)Cc2ccccc2)cc(c1)C(=O)Nc1ccc(cn1)C(O)=O

InChI Key InChIKey=OCBMECSFDVUYQN-ROUUACIJSA-N

Data  1 Kd  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50320996   

TargetHexokinase-4(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50320996(6-(3-((S)-1-methoxypropan-2-yloxy)-5-((S)-1-phenyl...)
Affinity DataEC50:  30nMAssay Description:Activation of human glucokinase expressed in Escherichia coli BL21(DE3) coexpressing G6PDH by spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-4(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50320996(6-(3-((S)-1-methoxypropan-2-yloxy)-5-((S)-1-phenyl...)
Affinity DataEC50:  30nMAssay Description:Activation of His-tagged recombinant glucokinase expressed in Escherichia coli using [14C]-glucose substrate by spectrophotometricallyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-4(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50320996(6-(3-((S)-1-methoxypropan-2-yloxy)-5-((S)-1-phenyl...)
Affinity DataKd:  3.30E+3nMAssay Description:Displacement of TAFMT from human pancreatic N-terminal His6-tagged glucokinase isoform 1 expressed in Escherichia coli BL21(DE3) by stopped-flow fluo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-4(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50320996(6-(3-((S)-1-methoxypropan-2-yloxy)-5-((S)-1-phenyl...)
Affinity DataEC50:  240nMAssay Description:Activation of human recombinant glucokinase expressed in Escherichia coli BL21(DE3) coexpressing G6PDH assessed as glucose 6-phosphate formation by s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-4(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50320996(6-(3-((S)-1-methoxypropan-2-yloxy)-5-((S)-1-phenyl...)
Affinity DataEC50:  45nMAssay Description:Activation of human recombinant glucokinase using 6.5 mM glucose by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed