BDBM50321467 (4-cyclobutyl-1,4-diazepan-1-yl)(6-(4-fluorophenoxy)pyridin-3-yl)methanone::CHEMBL1171754

SMILES Fc1ccc(Oc2ccc(cn2)C(=O)N2CCCN(CC2)C2CCC2)cc1

InChI Key InChIKey=IQOWHZHNGJXGHG-UHFFFAOYSA-N

Data  2 KI  2 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50321467   

TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321467((4-cyclobutyl-1,4-diazepan-1-yl)(6-(4-fluorophenox...)
Affinity DataKi:  1.40nMAssay Description:Displacement of [125I]-iodoproxyfan from human recombinant histamine H3 receptor expressed in human SK-N-MC cells after 1 hr by scintillation countin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321467((4-cyclobutyl-1,4-diazepan-1-yl)(6-(4-fluorophenox...)
Affinity DataKi:  23nMAssay Description:Binding affinity to histamine H3 receptor in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321467((4-cyclobutyl-1,4-diazepan-1-yl)(6-(4-fluorophenox...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human ERG by patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321467((4-cyclobutyl-1,4-diazepan-1-yl)(6-(4-fluorophenox...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of radiolabeled astemizole from human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321467((4-cyclobutyl-1,4-diazepan-1-yl)(6-(4-fluorophenox...)
Affinity DataKd:  3.55nMAssay Description:Antagonist activity at rat histamine H3 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-induced cAMP accumulation after...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed