BDBM50322743 8-chloro-N-(3-morpholinopropyl)-5H-pyrimido[5,4-b]indol-4-amine::CHEMBL597857::GNF-Pf-4478::cid_661700

SMILES Clc1ccc2[nH]c3c(NCCCN4CCOCC4)ncnc3c2c1

InChI Key InChIKey=ULJISGNQAXNPOC-UHFFFAOYSA-N

Data  1 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50322743   

TargetCruzipain(Trypanosoma cruzi)
University Of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50322743(8-chloro-N-(3-morpholinopropyl)-5H-pyrimido[5,4-b]...)
Affinity DataKi:  2.00E+3nMAssay Description:Inhibition of Trypanosoma cruzi cruzain assessed as Z-Phe-Arg-aminomethylcoumarin cleavage by competetive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine--tRNA ligase(Trypanosoma brucei brucei strain 927/4 GUTat10.1)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM50322743(8-chloro-N-(3-morpholinopropyl)-5H-pyrimido[5,4-b]...)
Affinity DataIC50:  9.10E+3nMMore data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCruzipain(Trypanosoma cruzi)
University Of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50322743(8-chloro-N-(3-morpholinopropyl)-5H-pyrimido[5,4-b]...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of Trypanosoma cruzi CruzainMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCruzipain(Trypanosoma cruzi)
University Of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50322743(8-chloro-N-(3-morpholinopropyl)-5H-pyrimido[5,4-b]...)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of recombinant Trypanosoma cruzi cruzain using Z-phe-Arg-amidomethylcoumarin as substrate by fluorometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)
University Of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50322743(8-chloro-N-(3-morpholinopropyl)-5H-pyrimido[5,4-b]...)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of Trypanosoma cruzi CruzainMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetInsulin-degrading enzyme(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM50322743(8-chloro-N-(3-morpholinopropyl)-5H-pyrimido[5,4-b]...)
Affinity DataIC50:  1.09E+4nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay