BDBM50323250 1-methyl-6-(4-(2-(piperidin-4-yl)ethoxy)-3-(trifluoromethyl)phenyl)-1H-imidazo[4,5-c]pyridine-4-carbonitrile::CHEMBL1209037::US9115126, WO 2009/010491, Example 14a

SMILES Cn1cnc2c(nc(cc12)-c1ccc(OCCC2CCNCC2)c(c1)C(F)(F)F)C#N

InChI Key InChIKey=PBHZOHMBRYRIGB-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50323250   

TargetCathepsin S(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50323250(1-methyl-6-(4-(2-(piperidin-4-yl)ethoxy)-3-(triflu...)
Affinity DataIC50:  8nMAssay Description:The inhibitory activity of the compounds of the invention was demonstrated in vitro by measuring the inhibition of recombinant human Cathepsin S as f...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCathepsin S(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50323250(1-methyl-6-(4-(2-(piperidin-4-yl)ethoxy)-3-(triflu...)
Affinity DataIC50:  8.30nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50323250(1-methyl-6-(4-(2-(piperidin-4-yl)ethoxy)-3-(triflu...)
Affinity DataIC50:  8.30nMAssay Description:Inhibition of human cathepsin S by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323250(1-methyl-6-(4-(2-(piperidin-4-yl)ethoxy)-3-(triflu...)
Affinity DataIC50:  178nMAssay Description:Inhibition of human cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323250(1-methyl-6-(4-(2-(piperidin-4-yl)ethoxy)-3-(triflu...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human cathepsin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50323250(1-methyl-6-(4-(2-(piperidin-4-yl)ethoxy)-3-(triflu...)
Affinity DataIC50:  9nMAssay Description:Inhibition of cathepsin S in human JY cells assessed as accumulation of lip10 by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin L2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323250(1-methyl-6-(4-(2-(piperidin-4-yl)ethoxy)-3-(triflu...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human cathepsin VMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323250(1-methyl-6-(4-(2-(piperidin-4-yl)ethoxy)-3-(triflu...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human cathepsin LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323250(1-methyl-6-(4-(2-(piperidin-4-yl)ethoxy)-3-(triflu...)
Affinity DataIC50:  178nMAssay Description:Inhibition of human cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50323250(1-methyl-6-(4-(2-(piperidin-4-yl)ethoxy)-3-(triflu...)
Affinity DataIC50:  9nMAssay Description:Inhibition of human cathepsin S by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed